Occurrence and correlates of symptom persistence following acute dengue fever in Peru

Eric S. Halsey, Maya Williams, V. Alberto Laguna-Torres, Stalin Vilcarromero, Victor Ocanã, Tadeusz J. Kochel, Morgan A. Marks

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Dengue virus (DENV) infection causes an acute febrile illness generally considered to result in either complete recovery or death. Some reviews describe persistent symptoms after the febrile phase, although empirical data supporting this phenomenon is scarce. We evaluated symptom persistence in acute febrile DENV-infected and DENV-negative (controls) individuals from Peru. Self-reported solicited symptoms were evaluated at an acute and a follow-up visit, occurring 10-60 days after symptom onset. Rate of persistence of at least one symptom was 7.7% and 10.5% for DENV infected and control subjects, respectively (P < 0.01). The DENV-infected individuals had lower rates of persistent respiratory symptoms, gastrointestinal symptoms, headache, and fatigue, but higher rates of persistent rash compared with controls. Older age and female gender were positively associated with symptom persistence. As dengue cases continue to increase annually, even a relatively low frequency of persistent symptoms may represent a considerable worldwide morbidity burden.

Original languageEnglish
Pages (from-to)449-456
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number3
StatePublished - Mar 2014
Externally publishedYes


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